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Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

Academic Article
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Overview

authors

  • Thomas, J. C.
  • O'Hara, J. M.
  • Hu, L.
  • Gao, F. P.
  • Joshi, S. B.
  • Volkin, D. B.
  • Brey, R. N.
  • Fang, J.
  • Karanicolas, John
  • Mantis, N. J.
  • Middaugh, C. R.

publication date

  • April 2013

journal

  • Human Vaccines & Immunotherapeutics  Journal

subject areas

  • Animals
  • Antibodies, Neutralizing
  • Antitoxins
  • Blood Glucose
  • Calorimetry
  • Circular Dichroism
  • Disease Models, Animal
  • Drug Stability
  • Mice
  • Mice, Inbred BALB C
  • Mutant Proteins
  • Point Mutation
  • Poisoning
  • Protein Conformation
  • Protein Stability
  • Ricin
  • Spectrometry, Fluorescence
  • Survival Analysis
  • Vaccines, Subunit
  • Vaccines, Synthetic
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Research

keywords

  • antigen
  • computational protein design
  • immunogenicity
  • protein stability
  • ricin
  • vaccine
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Identity

PubMed Central ID

  • PMC3903890

International Standard Serial Number (ISSN)

  • 2164-5515

Digital Object Identifier (DOI)

  • 10.4161/hv.22998

PubMed ID

  • 23563512
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Additional Document Info

start page

  • 744

end page

  • 752

volume

  • 9

issue

  • 4

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