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A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union

Academic Article
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Overview

authors

  • Grover, Rajesh
  • Zhu, X.
  • Nieusma, T.
  • Jones, T.
  • Boero, I.
  • MacLeod, A. S.
  • Mark, A.
  • Niessen, Sherry
  • Kim, H. J.
  • Kong, L.
  • Assad-Garcia, N.
  • Kwon, K.
  • Chesi, M.
  • Smider, Vaughn
  • Salomon, Daniel
  • Jelinek, D. F.
  • Kyle, R. A.
  • Pyles, R. B.
  • Glass, J. I.
  • Ward, Andrew
  • Wilson, Ian
  • Lerner, Richard

publication date

  • February 2014

journal

  • Science  Journal

abstract

  • We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the κ and λ light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field.

subject areas

  • Antigen-Antibody Reactions
  • Antigens
  • Bacterial Proteins
  • Crystallography, X-Ray
  • Humans
  • Immunoglobulin G
  • Immunoglobulin Variable Region
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • Lymphokines
  • Membrane Proteins
  • Mycoplasma
  • Protein Structure, Tertiary
  • Recombinant Proteins
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Identity

PubMed Central ID

  • PMC3987992

International Standard Serial Number (ISSN)

  • 1095-9203 (Electronic) 0036-8075 (Linking)

Digital Object Identifier (DOI)

  • 10.1126/science.1246135

PubMed ID

  • 24503852
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Additional Document Info

start page

  • 656

end page

  • 661

volume

  • 343

issue

  • 6171

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