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The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila

Academic Article
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  • Additional Document Info
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Overview

authors

  • Stanewsky, R.
  • Kaneko, M.
  • Emery, P.
  • Beretta, B.
  • Wager-Smith, K.
  • Kay, Steve A.
  • Rosbash, M.
  • Hall, J. C.

publication date

  • November 1998

journal

  • Cell  Journal

abstract

  • A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light normally suppresses TIM, cryb is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Behaviorally, cryb exhibits poor synchronization to light-dark cycles in genetic backgrounds that cause external blindness or demand several hours of daily rhythm resets, and it shows no response to brief light pulses. cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons.

subject areas

  • Animals
  • Behavior, Animal
  • Circadian Rhythm
  • Cryptochromes
  • Darkness
  • Drosophila Proteins
  • Drosophila melanogaster
  • Eye Proteins
  • Flavoproteins
  • Insect Proteins
  • Light
  • Mutation, Missense
  • Neurons
  • Nuclear Proteins
  • Open Reading Frames
  • Period Circadian Proteins
  • Photoreceptor Cells, Invertebrate
  • Receptors, G-Protein-Coupled
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)81638-4

PubMed ID

  • 9845370
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Additional Document Info

start page

  • 681

end page

  • 692

volume

  • 95

issue

  • 5

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