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A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells

Academic Article
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Overview

authors

  • Stubbs, K. A.
  • Macauley, Matthew
  • Vocadlo, D. J.

publication date

  • 2009

journal

  • Angewandte Chemie-International Edition  Journal

abstract

  • Gal-PUGNAc (see picture), a highly selective inhibitor for beta-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels. Gal-PUGNAc should allow the role of these enzymes to be studied at the cellular level without generating a complex chemical phenotype from concomitant inhibition of O-GlcNAcase.

subject areas

  • Cell Line, Tumor
  • Enzyme Inhibitors
  • G(M2) Ganglioside
  • Hexosaminidase A
  • Hexosaminidase B
  • Humans
  • Lysosomes
  • Neuroblastoma
  • Substrate Specificity
  • beta-N-Acetylhexosaminidases
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Research

keywords

  • carbohydrates
  • gangliosides
  • glycosidases
  • inhibitors
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.200804583

PubMed ID

  • 19130519
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Additional Document Info

start page

  • 1300

end page

  • 1303

volume

  • 48

issue

  • 7

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