Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development?

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Deryugina, Elena
  • Mullersieburg, C. E.

publication date

  • 1993

journal

  • Critical Reviews in Immunology  Journal

abstract

  • Long-term bone marrow cultures mirror many aspects of in vivo mammalian hematopoiesis. Thus, these cultures have been used widely to analyze the complex interactions that regulate hematopoietic differentiation. Hematopoiesis in vivo and in vitro is dependent on stromal cells, a mixture of support cells. In the past years numerous clonal stromal cell lines derived from murine and human tissues have been isolated and characterized. The stromal cell lines have proved to be invaluable tools for the elucidation of the molecular and cellular signals that govern differentiation and self-renewal of hematopoietic cells. This review describes the salient features of arrow cultures with a focus on the isolation and characterization of stromal cell lines. We summarize how stromal cell lines have been crucial tools for the detection, isolation, and maintenance of rare pluripotent stem cells and B lineage cells. Intriguing questions about the nature of stromal cells, their requirements for growth and differentiation, and their histogenic origin remain areas for further investigation.

subject areas

  • Animals
  • Bone Marrow Cells
  • Cell Adhesion
  • Cells, Cultured
  • Extracellular Matrix
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Phenotype
  • Stromal Cells
scroll to property group menus

Research

keywords

  • B-LINEAGE CELLS
  • DEXTER CULTURES
  • HEMATOPOIETIC MICROENVIRONMENT
  • PLURIPOTENT STEM CELLS
  • WHITLOCK-WITTE CULTURES
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1040-8401

PubMed ID

  • 8352908
scroll to property group menus

Additional Document Info

start page

  • 115

end page

  • 150

volume

  • 13

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support