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New aminocyclitols as modulators of glucosylceramide metabolism

Academic Article
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Overview

authors

  • Egido-Gabas, M.
  • Serrano-Navarro, Pedro
  • Casas, J.
  • Llebaria, A.
  • Delgado, A.

publication date

  • 2005

journal

  • Organic & Biomolecular Chemistry  Journal

abstract

  • A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure-activity relationships is provided.

subject areas

  • Enzyme Inhibitors
  • Glucosidases
  • Glucosylceramides
  • Hexosamines
  • Inositol
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Optical Rotation
  • Spectrometry, Mass, Electrospray Ionization
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 1477-0520

Digital Object Identifier (DOI)

  • 10.1039/b411473f

PubMed ID

  • 15785807
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Additional Document Info

start page

  • 1195

end page

  • 1201

volume

  • 3

issue

  • 7

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