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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia

Academic Article
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Overview

authors

  • Roecker, Anthony
  • Mercer, S. P.
  • Schreier, J. D.
  • Cox, C. D.
  • Fraley, M. E.
  • Steen, J. T.
  • Lemaire, W.
  • Bruno, J. G.
  • Harrell, C. M.
  • Garson, S. L.
  • Gotter, A. L.
  • Fox, S. V.
  • Stevens, J.
  • Tannenbaum, P. L.
  • Prueksaritanont, T.
  • Cabalu, T. D.
  • Cui, D.
  • Stellabott, J.
  • Hartman, G. D.
  • Young, S. D.
  • Winrow, C. J.
  • Renger, J. J.
  • Coleman, P. J.

publication date

  • February 2014

journal

  • Chemmedchem  Journal

subject areas

  • Animals
  • Dogs
  • Drug Design
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Macaca mulatta
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neuropeptides
  • Orexins
  • Pyridines
  • Rats
  • Rats, Sprague-Dawley
  • Sleep Initiation and Maintenance Disorders
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Research

keywords

  • antagonists
  • insomnia
  • medicinal chemistry
  • neurotransmitters
  • orexin receptors
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Identity

International Standard Serial Number (ISSN)

  • 1860-7179

Digital Object Identifier (DOI)

  • 10.1002/cmdc.201300447

PubMed ID

  • 24376006
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Additional Document Info

start page

  • 311

end page

  • 322

volume

  • 9

issue

  • 2

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