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Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

Academic Article
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Overview

authors

  • Cramer, S. L.
  • Saha, A.
  • Liu, J.
  • Tadi, S.
  • Tiziani, S.
  • Yan, W.
  • Triplett, K.
  • Lamb, C.
  • Alters, S. E.
  • Rowlinson, S.
  • Zhang, Yan Jessie
  • Keating, M. J.
  • Huang, P.
  • DiGiovanni, J.
  • Georgiou, G.
  • Stone, E.

publication date

  • January 2017

journal

  • Nature Medicine  Journal

subject areas

  • Animals
  • Blotting, Western
  • Breast Neoplasms
  • Cell Line, Tumor
  • Cystathionine gamma-Lyase
  • Cysteine
  • Cystine
  • Female
  • Glutathione
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Macaca fascicularis
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Neoplasm Transplantation
  • Oxidative Stress
  • Polyethylene Glycols
  • Prostatic Neoplasms
  • Reactive Oxygen Species
  • Tumor Suppressor Protein p53
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Identity

PubMed Central ID

  • PMC5218918

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm.4232 https://www.nature.com/articles/nm.4232#supplementary-information

PubMed ID

  • 27869804
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Additional Document Info

start page

  • 120

end page

  • 127

volume

  • 23

issue

  • 1

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