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Cell active hydroxylactam inhibitors of human lactate dehydrogenase with oral bioavailability in mice

Academic Article
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Overview

authors

  • Purkey, Hans
  • Robarge, K.
  • Chen, J.
  • Chen, Z.
  • Corson, L. B.
  • Ding, C. Z.
  • DiPasquale, A. G.
  • Dragovich, P. S.
  • Eigenbrot, C.
  • Evangelista, M.
  • Fauber, B. P.
  • Gao, Z.
  • Ge, H.
  • Hitz, A.
  • Ho, Q.
  • Labadie, S. S.
  • Lai, K.
  • Liu, W.
  • Liu, Y.
  • Li, C.
  • Ma, S.
  • Malek, S.
  • O'Brien, T.
  • Pang, J.
  • Peterson, D.
  • Salphati, L.
  • Sideris, S.
  • Ultsch, M.
  • Wei, B.
  • Yen, I.
  • Yue, Q.
  • Zhang, H.
  • Zhou, A.

publication date

  • October 2016

journal

  • ACS Medicinal Chemistry Letters  Journal
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Research

keywords

  • Lactate dehydrogenase
  • X-ray crystal structure
  • glycolysis
  • structure-based design
  • tumor metabolism
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Identity

PubMed Central ID

  • PMC5066143

International Standard Serial Number (ISSN)

  • 1948-5875

Digital Object Identifier (DOI)

  • 10.1021/acsmedchemlett.6b00190

PubMed ID

  • 27774125
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Additional Document Info

start page

  • 896

end page

  • 901

volume

  • 7

issue

  • 10

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