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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Academic Article
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  • Overview
  • Research
  • Identity
  • Additional Document Info
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Overview

authors

  • Liu, J.
  • Pan, S.
  • Hsieh, M. H.
  • Ng, N.
  • Sun, F.
  • Wang, T.
  • Kasibhatla, S.
  • Schuller, A. G.
  • Li, A. G.
  • Cheng, D.
  • Li, J.
  • Tompkins, C.
  • Pferdekamper, A.
  • Steffy, A.
  • Cheng, J.
  • Kowal, C.
  • Phung, V.
  • Guo, G.
  • Wang, Y.
  • Graham, M. P.
  • Flynn, S.
  • Brenner, J. C.
  • Li, C.
  • Villarroel, M. C.
  • Schultz, P. G.
  • Wu, Xu
  • McNamara, P.
  • Sellers, W. R.
  • Petruzzelli, L.
  • Boral, A. L.
  • Seidel, H. M.
  • McLaughlin, M. E.
  • Che, J.
  • Carey, T. E.
  • Vanasse, G.
  • Harris, J. L.

publication date

  • 2013

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

subject areas

  • Acyltransferases
  • Animals
  • Axin Protein
  • Blotting, Western
  • Cell Line, Tumor
  • Cloning, Molecular
  • High-Throughput Screening Assays
  • Humans
  • Membrane Proteins
  • Mice
  • Mutagenesis
  • Neoplasms
  • Phosphorylation
  • Pyrazines
  • Pyridines
  • Radioligand Assay
  • Rats
  • Receptors, Notch
  • Reverse Transcriptase Polymerase Chain Reaction
  • Wnt Signaling Pathway
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Research

keywords

  • HNSCC
  • Wnt inhibition
  • beta-catenin
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Identity

PubMed Central ID

  • PMC3864356

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1314239110

PubMed ID

  • 24277854
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Additional Document Info

start page

  • 20224

end page

  • 20229

volume

  • 110

issue

  • 50

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