Practical Ni-catalyzed aryl-alkyl cross-coupling of secondary redox-active esters

Academic Article
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publication date

  • February 2016

abstract

  • A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis. The success of this reaction hinges on the unique use of redox-active esters that allow one to employ such derivatives as alkyl halides surrogates. The chemistry exhibits broad substrate scope and features a high degree of practicality. The simple procedure and extremely inexpensive nature of both the substrates and pre-catalyst (NiCl2ยท6H2O, ca. $9.5/mol) bode well for the immediate widespread adoption of this method.