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Progress and prospects: RNA-based therapies for treatment of HIV infection

Academic Article
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Overview

authors

  • Scherer, L.
  • Rossi, J. J.
  • Weinberg, Marc

publication date

  • July 2007

journal

  • Gene Therapy  Journal

abstract

  • The current treatment regimen for HIV-infected individuals combines two or more drugs targeting different viral proteins such as RT and gag. Resistance to conventional drugs can develop quickly, and typically persists. The prospect of longer, continuous antiretroviral therapy brings with it the need for new antiretroviral drugs and approaches. In this context, gene therapies have the potential to prolong life and quality of life as an additional therapeutic class and may serve as an adjuvant to traditional treatments. This review focuses on RNA-based hematopoietic cell gene therapy for treatment of HIV infection. Recent advances in our understanding of RNA interference (RNAi) make this an especially attractive candidate for anti-HIV gene therapy although ribozyme and RNA decoy/aptamer approaches can be combined with RNAi to make a combinatorial therapy akin to highly active anti-retroviral therapy.

subject areas

  • Anti-HIV Agents
  • Combined Modality Therapy
  • Genes, Viral
  • Genetic Therapy
  • HIV Infections
  • HIV-1
  • Humans
  • RNA Interference
  • RNA, Antisense
  • RNA, Small Interfering
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Research

keywords

  • HIV-1
  • RNAi
  • aptamer
  • ribozyme
  • siRNA
  • therapy
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Identity

International Standard Serial Number (ISSN)

  • 0969-7128

Digital Object Identifier (DOI)

  • 10.1038/sj.gt.3302977

PubMed ID

  • 17607313
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Additional Document Info

start page

  • 1057

end page

  • 1064

volume

  • 14

issue

  • 14

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