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B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

Academic Article
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Overview

authors

  • Huang, D. L.
  • Abbott, R. K.
  • Havenar-Daughton, C.
  • Skog, P. D.
  • Al-Kolla, R.
  • Groschel, B.
  • Blane, T. R.
  • Menis, S.
  • Tran, J. T.
  • Thinnes, T. C.
  • Volpi, S. A.
  • Liguori, A.
  • Schiffner, T.
  • Villegas, S. M.
  • Kalyuzhniy, O.
  • Pintea, M.
  • Voss, James
  • Phelps, N.
  • Tingle, R.
  • Rodriguez, A. R.
  • Martin, G.
  • Kupryianov, S.
  • deCamp, A.
  • Schief, William
  • Nemazee, David
  • Crotty, Shane

publication date

  • September 1, 2020

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

subject areas

  • AIDS Vaccines
  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Antigens, CD4
  • B-Lymphocytes
  • Broadly Neutralizing Antibodies
  • Gene Knock-In Techniques
  • Germinal Center
  • HIV Antibodies
  • HIV Antigens
  • HIV Infections
  • HIV-1
  • Humans
  • Mice
  • Mice, Inbred Strains
  • Mice, Transgenic
  • Precursor Cells, B-Lymphoid
  • Receptors, Antigen, B-Cell
  • Vaccination
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Identity

PubMed Central ID

  • PMC7502816

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.2004489117

PubMed ID

  • 32873644
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Additional Document Info

start page

  • 22920

end page

  • 22931

volume

  • 117

issue

  • 37

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