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Minimizing CYP2C9 inhibition of exposed-pyridine NAMPT (nicotinamide phosphoribosyltransferase) inhibitors

Academic Article
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Overview

authors

  • Zak, Mark
  • Yuen, P. W.
  • Liu, X.
  • Patel, S.
  • Sampath, D.
  • Oeh, J.
  • Liederer, B. M.
  • Wang, W.
  • O'Brien, T.
  • Xiao, Y.
  • Skelton, N.
  • Hua, R.
  • Sodhi, J.
  • Wang, Y.
  • Zhang, L.
  • Zhao, G.
  • Zheng, X.
  • Ho, Y. C.
  • Bair, K. W.
  • Dragovich, P. S.

publication date

  • September 2016

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Animals
  • Antineoplastic Agents
  • Cell Line, Tumor
  • Cytochrome P-450 CYP2C9
  • Cytochrome P-450 CYP2C9 Inhibitors
  • Drug Discovery
  • Enzyme Inhibitors
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Models, Molecular
  • Neoplasms
  • Nicotinamide Phosphoribosyltransferase
  • Pyridines
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.6b00697

PubMed ID

  • 27541271
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Additional Document Info

start page

  • 8345

end page

  • 8368

volume

  • 59

issue

  • 18

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