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Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipase

Academic Article
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Overview

authors

  • Kolar, M. J.
  • Kamat, S. S.
  • Parsons, W. H.
  • Homan, E. A.
  • Maher, T.
  • Peroni, O. D.
  • Syed, I.
  • Fjeld, K.
  • Molven, A.
  • Kahn, B. B.
  • Cravatt, Benjamin
  • Saghateliann, A.

publication date

  • August 2016

journal

  • Biochemistry  Journal

abstract

  • A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary lipids, as a FAHFA hydrolase. Variants of CEL have been linked to maturity-onset diabetes of the young, type 8 (MODY8), and to chronic pancreatitis. We tested the FAHFA hydrolysis activity of the CEL MODY8 variant and found a modest increase in activity as compared with that of the normal enzyme. Together, the data suggest that CEL might break down dietary FAHFAs.
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Identity

PubMed Central ID

  • PMC5056623

International Standard Serial Number (ISSN)

  • 0006-2960

Digital Object Identifier (DOI)

  • 10.1021/acs.biochem.6b00565

PubMed ID

  • 27509211
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Additional Document Info

start page

  • 4636

end page

  • 4641

volume

  • 55

issue

  • 33

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