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Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell Lymphoma Models

Academic Article
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Overview

authors

  • Davis, M. I.
  • Pragani, Rajan
  • Fox, J. T.
  • Shen, M.
  • Parmar, K.
  • Gaudiano, E. F.
  • Liu, L.
  • Tanega, C.
  • McGee, L.
  • Hall, M. D.
  • McKnight, C.
  • Shinn, P.
  • Nelson, H.
  • Chattopadhyay, D.
  • D'Andrea, A. D.
  • Auld, D. S.
  • DeLucas, L. J.
  • Li, Z.
  • Boxer, M. B.
  • Sinneonov, A.

publication date

  • November 2016

journal

  • Journal of Biological Chemistry  Journal

subject areas

  • Cell Cycle Checkpoints
  • Cell Line, Tumor
  • Colorectal Neoplasms
  • Cyclin D1
  • DNA Damage
  • DNA Repair
  • Endopeptidases
  • Humans
  • Lymphoma, Mantle-Cell
  • Neoplasm Proteins
  • Protease Inhibitors
  • Proteolysis
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Identity

PubMed Central ID

  • PMC5114414

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M116.738567

PubMed ID

  • 27681596
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Additional Document Info

start page

  • 24628

end page

  • 24640

volume

  • 291

issue

  • 47

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