Ligand-promoted alkylation of C(sp(3))-H and C(sp(2))-H bonds Academic Article uri icon

publication date

  • 2014


  • 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))-H and C(sp(2))-H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.