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Incorporation of phosphonate into benzonaphthyridine toll-like receptor 7 agonists for adsorption to aluminum hydroxide

Academic Article
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Overview

authors

  • Cortez, A.
  • Li, Y.
  • Miller, A. T.
  • Zhang, X.
  • Yue, K.
  • Maginnis, J.
  • Hampton, J.
  • Hall, D. S.
  • Shapiro, M.
  • Nayak, B.
  • D'Oro, U.
  • Li, C.
  • Skibinski, D.
  • Mbow, M. L.
  • Singh, M.
  • O'Hagan, D. T.
  • Cooke, M. P.
  • Valiante, N. M.
  • Wu, Tom

publication date

  • June 2016

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Adsorption
  • Aluminum Hydroxide
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Injections, Intramuscular
  • Leukocytes, Mononuclear
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
  • Naphthyridines
  • Organophosphonates
  • Spleen
  • Structure-Activity Relationship
  • Toll-Like Receptor 7
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.6b00489

PubMed ID

  • 27270029
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Additional Document Info

start page

  • 5868

end page

  • 5878

volume

  • 59

issue

  • 12

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