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The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors

Academic Article
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Overview

authors

  • Buynak, J. D.
  • Doppalapudi, V. R.
  • Rao, A. S.
  • Nidamarthy, S. D.
  • Adam, Gregory

publication date

  • 2000

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • A series of 2-substituted-7-(alkylidene)cephalosporin sulfones were prepared and evaluated as beta-lactamase inhibitors. Compound 11c showed excellent activity as an inhibitor of the class C beta-lactamase derived from Enterobacter cloacae, strain P99.

subject areas

  • Alkenes
  • Cephalosporins
  • Enterobacter cloacae
  • Enzyme Inhibitors
  • Staphylococcus aureus
  • Structure-Activity Relationship
  • beta-Lactamase Inhibitors
  • beta-Lactamases
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(00)00094-9

PubMed ID

  • 10853645
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Additional Document Info

start page

  • 847

end page

  • 851

volume

  • 10

issue

  • 9

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