Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

Academic Article

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• Research
• Identity
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Overview

authors

• Ameriks, M. K.
• Bembenek, S. D.
• Burdett, M. T.
• Choong, I. C.
• Edwards, J. P.
• Gebauer, D.
• Gu, Y.
• Karlsson, L.
• Purkey, Hans
• Staker, B. L.
• Sun, S.
• Thurmond, R. L.
• Zhu, J.

publication date

• July 2010

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

• Cathepsins
• Crystallography, X-Ray
• Models, Molecular
• Protease Inhibitors
• Pyrazoles
• Structure-Activity Relationship

Research

keywords

• Cathepsin
• Fragment-based screening
• Protease
• Tethering
• X-ray crystallography

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2010.05.086

PubMed ID

• 20541404

Additional Document Info

start page

• 4060

end page

• 4064

volume

• 20

issue

• 14