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Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

Academic Article
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  • Research
  • Identity
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Overview

authors

  • Ameriks, M. K.
  • Bembenek, S. D.
  • Burdett, M. T.
  • Choong, I. C.
  • Edwards, J. P.
  • Gebauer, D.
  • Gu, Y.
  • Karlsson, L.
  • Purkey, Hans
  • Staker, B. L.
  • Sun, S.
  • Thurmond, R. L.
  • Zhu, J.

publication date

  • July 2010

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Cathepsins
  • Crystallography, X-Ray
  • Models, Molecular
  • Protease Inhibitors
  • Pyrazoles
  • Structure-Activity Relationship
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Research

keywords

  • Cathepsin
  • Fragment-based screening
  • Protease
  • Tethering
  • X-ray crystallography
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2010.05.086

PubMed ID

  • 20541404
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Additional Document Info

start page

  • 4060

end page

  • 4064

volume

  • 20

issue

  • 14

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