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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates

Academic Article
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  • Research
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Overview

authors

  • Barrett, S. E.
  • Burke, R. S.
  • Abrams, M. T.
  • Bason, C.
  • Busuek, M.
  • Carlini, E.
  • Carr, B. A.
  • Crocker, L. S.
  • Fan, H.
  • Garbaccio, Robert
  • Guidry, E. N.
  • Heo, J. H.
  • Howell, B. J.
  • Kemp, E. A.
  • Kowtoniuk, R. A.
  • Latham, A. H.
  • Leone, A. M.
  • Lyman, M.
  • Parmar, R. G.
  • Patel, M.
  • Pechenov, S. Y.
  • Pei, T.
  • Pudvah, N. T.
  • Raab, C.
  • Riley, S.
  • Sepp-Lorenzino, L.
  • Smith, S.
  • Soli, E. D.
  • Staskiewicz, S.
  • Stern, M.
  • Truong, Q.
  • Vavrek, M.
  • Waldman, J. H.
  • Walsh, E. S.
  • Williams, J. M.
  • Young, S.
  • Colletti, S. L.

publication date

  • June 2014

journal

  • Journal of Controlled Release  Journal

subject areas

  • Animals
  • Autoradiography
  • Biocompatible Materials
  • Drug Carriers
  • Drug Design
  • Drug Stability
  • Female
  • Hep G2 Cells
  • Hepatocytes
  • Humans
  • Liver
  • Macaca mulatta
  • Nylons
  • Peptides
  • RNA, Small Interfering
  • Radionuclide Imaging
  • Rats, Sprague-Dawley
  • Species Specificity
  • Structure-Activity Relationship
  • Tissue Distribution
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Research

keywords

  • Biodegradable
  • Delivery vehicle
  • Gene delivery
  • Polypeptide
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Identity

International Standard Serial Number (ISSN)

  • 0168-3659

Digital Object Identifier (DOI)

  • 10.1016/j.jconrel.2014.03.028

PubMed ID

  • 24657948
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Additional Document Info

start page

  • 124

end page

  • 137

volume

  • 183

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