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The evolution of cefotaximase activity in the TEM β-lactamase

Academic Article
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Overview

authors

  • Singh, M. K.
  • Dominy, Brian

publication date

  • January 2012

journal

  • Journal of Molecular Biology  Journal

subject areas

  • Anti-Bacterial Agents
  • Binding Sites
  • Catalysis
  • Crystallography, X-Ray
  • Drug Resistance, Bacterial
  • Evolution, Molecular
  • Hydrogen Bonding
  • Kinetics
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Point Mutation
  • Protein Binding
  • Protein Conformation
  • beta-Lactamases
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Research

keywords

  • MM-GBSA
  • TEM beta-lactamase
  • catalytic activity
  • enzymatic evolution
  • molecular dynamics
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Identity

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1016/j.jmb.2011.10.041

PubMed ID

  • 22075446
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Additional Document Info

start page

  • 205

end page

  • 220

volume

  • 415

issue

  • 1

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