recent publications

• academic article

  • Zhang, W., Dourado, Dfar, Mannervik, B. Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates Biochimica Et Biophysica Acta-General Subjects  2015 1850:742-749  DOI:10.1016/j.bbagen.2014.12.021  PMID:25542299
  • Dourado, Dfar, Fernandes, P. A., Mannervik, B., Ramos, M. J. Isomerization of Δ5-androstene-3,17-dione into Δ4-androstene-3,17-dione catalyzed by human glutathione transferase A3-3: a computational study identifies a dual role for glutathione Journal of Physical Chemistry A  2014 118:5790-5800  DOI:10.1021/jp410810q  PMID:24739064
  • Dourado, Dfar, Fernandes, P. A., Ramos, M. J., Mannervik, B. Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA) Biochemistry  2013 52:8069-8078  DOI:10.1021/bi4005705  PMID:24066958
  • Dourado, Dfar, Fernandes, P. A., Mannervik, B., Ramos, M. J. Glutathione transferase A1-1: catalytic importance of arginine 15 Journal of Physical Chemistry B  2010 114:1690-1697  DOI:10.1021/jp908251z  PMID:20052987
  • Dourado, Dfar, Fernandes, P. A., Mannervik, B., Ramos, M. J. Glutathione transferase: new model for glutathione activation Chemistry-a European Journal  2008 14:9591-9598  DOI:10.1002/chem.200800946  PMID:18792041