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Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models

Academic Article
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  • Research
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Overview

authors

  • Mallari, J. P.
  • Zhu, F.
  • Lemoff, A.
  • Kaiser, M.
  • Lu, M.
  • Brun, R.
  • Guy, Rodney Kiplin

publication date

  • December 2010

journal

  • Bioorganic & Medicinal Chemistry  Journal

subject areas

  • Administration, Oral
  • Animals
  • Cysteine Endopeptidases
  • Disease Models, Animal
  • Humans
  • Mice
  • Nitriles
  • Protease Inhibitors
  • Purines
  • Trypanocidal Agents
  • Trypanosoma brucei brucei
  • Trypanosomiasis, African
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Research

keywords

  • Human African trypanosomiasis
  • Parasite
  • Protease inhibitor
  • TbCatB
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/j.bmc.2010.09.073

PubMed ID

  • 21051236
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Additional Document Info

start page

  • 8302

end page

  • 8309

volume

  • 18

issue

  • 23

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