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Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Academic Article
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Overview

authors

  • Thomas, Allen
  • Le Huerou, Y.
  • De Meese, J.
  • Gunawardana, I.
  • Kaplan, T.
  • Romoff, T. T.
  • Gonzales, S. S.
  • Condroski, K.
  • Boyd, S. A.
  • Ballard, J.
  • Bernat, B.
  • DeWolf, W.
  • Han, M.
  • Lee, P.
  • Lemieux, C.
  • Pedersen, R.
  • Pheneger, J.
  • Poch, G.
  • Smith, D.
  • Sullivan, F.
  • Weiler, S.
  • Wright, S. K.
  • Lin, J.
  • Brandhuber, B.
  • Vigers, G.

publication date

  • March 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Colonic Neoplasms
  • Crystallography, X-Ray
  • Enzyme Inhibitors
  • Glucosephosphate Dehydrogenase
  • Humans
  • In Vitro Techniques
  • Ketoglutarate Dehydrogenase Complex
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Nude
  • Molecular Structure
  • Oxythiamine
  • Phosphorylation
  • Spleen
  • Structure-Activity Relationship
  • Thiamine
  • Transketolase
  • Xenograft Model Antitumor Assays
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Research

keywords

  • cancer
  • metabolism
  • pyrophosphate
  • thiamine
  • transketolase
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.11.101

PubMed ID

  • 18267359
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Additional Document Info

start page

  • 2206

end page

  • 2210

volume

  • 18

issue

  • 6

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