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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

Academic Article
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  • Identity
  • Additional Document Info
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Overview

authors

  • Hall, J.
  • Brault, A.
  • Vincent, F.
  • Weng, S.
  • Wang, H.
  • Dumlao, D.
  • Aulabaugh, A.
  • Aivazian, D.
  • Castro, D.
  • Chen, M.
  • Culp, J.
  • Dower, K.
  • Gardner, J.
  • Hawrylik, S.
  • Golenbock, D.
  • Hepworth, D.
  • Horn, M.
  • Jones, L.
  • Jones, P.
  • Latz, E.
  • Li, J.
  • Lin, L. L.
  • Lin, W.
  • Lin, David Wei
  • Lovering, F.
  • Niljanskul, N.
  • Nistler, R.
  • Pierce, B.
  • Plotnikova, O.
  • Schmitt, D.
  • Shanker, S.
  • Smith, J.
  • Snyder, W.
  • Subashi, T.
  • Trujillo, John I
  • Tyminski, E.
  • Wang, G.
  • Wong, J.
  • Lefker, B.
  • Dakin, L.
  • Leach, K.

publication date

  • September 2017

journal

  • PLoS One  Journal

subject areas

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies
  • Drug Discovery
  • Enzyme Inhibitors
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescence Polarization
  • Humans
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Structure
  • Nucleotides, Cyclic
  • Nucleotidyltransferases
  • Protein Binding
  • Pyrazoles
  • Pyrimidines
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Identity

PubMed Central ID

  • PMC5608272

International Standard Serial Number (ISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0184843

PubMed ID

  • 28934246
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Additional Document Info

volume

  • 12

issue

  • 9

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