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Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase

Academic Article
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  • Research
  • Identity
  • Additional Document Info
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Overview

authors

  • Sweeney, Z. K.
  • Dunn, J. P.
  • Li, Y.
  • Heilek, G.
  • Dunten, P.
  • Elworthy, T. R.
  • Han, X.
  • Harris, S. F.
  • Hirschfeld, D. R.
  • Hogg, Heather
  • Huber, W.
  • Kaiser, A. C.
  • Kertesz, D. J.
  • Kim, W.
  • Mirzadegan, T.
  • Roepel, M. G.
  • Saito, Y. D.
  • Silva, Tmpc
  • Swallow, S.
  • Tracy, J. L.
  • Villasenor, A.
  • Vora, H.
  • Zhou, A. S.
  • Klumpp, K.

publication date

  • 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Dogs
  • Drug Resistance, Viral
  • HIV Reverse Transcriptase
  • Inhibitory Concentration 50
  • Molecular Structure
  • Pyridazines
  • Rats
  • Reverse Transcriptase Inhibitors
  • Structure-Activity Relationship
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Research

keywords

  • HIV
  • NNRTI
  • human immunodeficiency virus
  • non-nucleoside
  • reverse transcriptase
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.06.072

PubMed ID

  • 18632268
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Additional Document Info

start page

  • 4352

end page

  • 4354

volume

  • 18

issue

  • 15

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