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Identification of covalent bromodomain binders through DNA display of small molecules

Academic Article
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Overview

authors

  • Daguer, J. P.
  • Zambaldo, C.
  • Abegg, D.
  • Barluenga, S.
  • Tallant, C.
  • Muller, S.
  • Adibekian, Alexander
  • Winssinger, Nicolas

publication date

  • May 2015

journal

  • Angewandte Chemie-International Edition  Journal

subject areas

  • Binding Sites
  • Cysteine
  • DNA
  • Epigenesis, Genetic
  • Ethacrynic Acid
  • Humans
  • Models, Molecular
  • Molecular Probes
  • Molecular Structure
  • Protein Structure, Tertiary
  • Proteomics
  • Small Molecule Libraries
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Research

keywords

  • activity-based proteomic profiling
  • bromodomains
  • covalent inhibitors
  • microarrays
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.201412276

PubMed ID

  • 25772490
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Additional Document Info

start page

  • 6057

end page

  • 6061

volume

  • 54

issue

  • 20

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