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Duplication, degeneration and subfunctionalization of the nested synapsin-Timp genes in Fugu

Academic Article
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Overview

authors

  • Yu, W. P.
  • Brenner, Sydney
  • Venkatesh, B.

publication date

  • April 2003

journal

  • Trends in Genetics  Journal

abstract

  • The genes encoding synapsin (Syn) and the tissue inhibitor of metalloproteinase (Timp) exhibit a nested organization that is conserved in fruit fly and vertebrates. Analysis of the human and Fugu genomes show that the evolution of Syn-Timp gene families is characterized by duplications, secondary loss and the partitioning of ancestral functions. Of particular interest are two duplicate Syn-Timp loci in Fugu that have accumulated complementary degenerate mutations such that each Syn duplicate produces one of the two transcripts generated from the single ancestral gene, and one of the Timp genes is lost.

subject areas

  • Alternative Splicing
  • Animals
  • Evolution, Molecular
  • Gene Duplication
  • Humans
  • Phylogeny
  • Protein Isoforms
  • Sequence Analysis, DNA
  • Synapsins
  • Synteny
  • Takifugu
  • Tissue Inhibitor of Metalloproteinases
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Identity

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/s0168-9525(03)00048-9

PubMed ID

  • 12683968
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Additional Document Info

start page

  • 180

end page

  • 183

volume

  • 19

issue

  • 4

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