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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Academic Article
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  • Research
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Overview

authors

  • Zheng, X.
  • Bair, K. W.
  • Bauer, P.
  • Baumeister, T.
  • Bowman, K. K.
  • Buckmelter, A. J.
  • Caligiuri, M.
  • Clodfelter, K. H.
  • Feng, Y.
  • Han, B.
  • Ho, Y. C.
  • Kley, N.
  • Li, H.
  • Liang, X.
  • Liederer, B. M.
  • Lin, J.
  • Ly, J.
  • O'Brien, T.
  • Oeh, J.
  • Oh, A.
  • Reynolds, D. J.
  • Sampath, D.
  • Sharma, G.
  • Skelton, N.
  • Smith, C. C.
  • Tremayne, J.
  • Wang, L.
  • Wang, W.
  • Wang, Z.
  • Wu, H.
  • Wu, J.
  • Xiao, Y.
  • Yang, G.
  • Yuen, P. W.
  • Zak, Mark
  • Dragovich, P. S.

publication date

  • October 2013

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Amides
  • Animals
  • Binding Sites
  • Carboxylic Acids
  • Cell Line, Tumor
  • Cell Proliferation
  • Crystallography, X-Ray
  • Cytokines
  • Enzyme Inhibitors
  • Female
  • Half-Life
  • Haplorhini
  • Humans
  • Mice
  • Mice, Nude
  • NAD
  • Niacinamide
  • Nicotinamide Phosphoribosyltransferase
  • Protein Structure, Tertiary
  • Pyrazoles
  • Pyridines
  • Rats
  • Retina
  • Structure-Activity Relationship
  • Sulfones
  • Transplantation, Heterologous
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Research

keywords

  • Nicotinamide phosphoribosyltransferase (NAMPT)
  • Tumor metabolism
  • X-ray crystal structure
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2013.08.074

PubMed ID

  • 24021463
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Additional Document Info

start page

  • 5488

end page

  • 5497

volume

  • 23

issue

  • 20

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