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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Academic Article
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  • Identity
  • Additional Document Info
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Overview

authors

  • Lien, E. C.
  • Lyssiotis, Costas A
  • Juvekar, A.
  • Hu, H.
  • Asara, J. M.
  • Cantley, L. C.
  • Toker, A.

publication date

  • May 2016

journal

  • Nature Cell Biology  Journal

subject areas

  • Biosynthetic Pathways
  • Breast Neoplasms
  • Buthionine Sulfoximine
  • Cell Line, Tumor
  • Cisplatin
  • Female
  • Glutathione
  • Humans
  • Mutation
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction
  • Spheroids, Cellular
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Identity

PubMed Central ID

  • PMC4848114

International Standard Serial Number (ISSN)

  • 1465-7392

Digital Object Identifier (DOI)

  • 10.1038/ncb3341

PubMed ID

  • 27088857
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Additional Document Info

start page

  • 572

end page

  • 578

volume

  • 18

issue

  • 5

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