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Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists

Academic Article
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Overview

authors

  • Dounay, A. B.
  • Barta, N. S.
  • Campbell, B. M.
  • Coleman, C.
  • Collantes, E. M.
  • Denny, L.
  • Dutta, S.
  • Gray, David
  • Hou, D. F.
  • Iyer, R.
  • Maiti, S. N.
  • Ortwine, D. F.
  • Probert, A.
  • Stratman, N. C.
  • Subedi, R.
  • Whisman, T.
  • Xu, W.
  • Zoski, K.

publication date

  • 2010

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Adrenergic Uptake Inhibitors
  • Cell Line
  • Crystallography, X-Ray
  • Drug Design
  • Drug Evaluation, Preclinical
  • Humans
  • Microsomes, Liver
  • Norepinephrine Plasma Membrane Transport Proteins
  • Phenols
  • Pyridines
  • Receptor, Serotonin, 5-HT1A
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin Receptor Agonists
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Research

keywords

  • 5-HT1A partial agonist
  • Norepinephrine reuptake inhibitor
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.12.023

PubMed ID

  • 20031410
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Additional Document Info

start page

  • 1114

end page

  • 1117

volume

  • 20

issue

  • 3

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