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Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Academic Article
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Overview

authors

  • Pfefferkorn, Jeff
  • Guzman-Perez, A.
  • Litchfield, J.
  • Aiello, R.
  • Treadway, J. L.
  • Pettersen, J.
  • Minich, M. L.
  • Filipski, K. J.
  • Jones, C. S.
  • Tu, M.
  • Aspnes, G.
  • Risley, H.
  • Bian, J.
  • Stevens, B. D.
  • Bourassa, P.
  • D'Aquila, T.
  • Baker, L.
  • Barucci, N.
  • Robertson, A. S.
  • Bourbonais, F.
  • Derksen, D. R.
  • MacDougall, M.
  • Cabrera, O.
  • Chen, J.
  • Lapworth, A. L.
  • Landro, J. A.
  • Zavadoski, W. J.
  • Atkinson, K.
  • Haddish-Berhane, N.
  • Tan, B.
  • Yao, L.
  • Kosa, R. E.
  • Varma, M. V.
  • Feng, B.
  • Duignan, D. B.
  • El-Kattan, A.
  • Murdande, S.
  • Liu, S.
  • Ammirati, M.
  • Knafels, J.
  • DaSilva-Jardine, P.
  • Sweet, L.
  • Liras, S.
  • Rolph, T. P.

publication date

  • February 2012

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Allosteric Site
  • Animals
  • Blood Glucose
  • Diabetes Mellitus, Type 2
  • Dogs
  • Enzyme Activators
  • Glucokinase
  • Haplorhini
  • Hepatocytes
  • Humans
  • Hypoglycemic Agents
  • Imidazoles
  • In Vitro Techniques
  • Insulin-Secreting Cells
  • Male
  • Models, Molecular
  • Nicotinic Acids
  • Organic Anion Transporters
  • Protein Binding
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tissue Distribution
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm2014887

PubMed ID

  • 22196621
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Additional Document Info

start page

  • 1318

end page

  • 1333

volume

  • 55

issue

  • 3

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