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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Academic Article
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Overview

authors

  • Pacold, M. E.
  • Brimacombe, K. R.
  • Chan, S. H.
  • Rohde, Jason
  • Lewis, C. A.
  • Swier, Ljym
  • Possemato, R.
  • Chen, W. W.
  • Sullivan, L. B.
  • Fiske, B. P.
  • Cho, S.
  • Freinkman, E.
  • Birsoy, K.
  • Abu-Remaileh, M.
  • Shaul, Y. D.
  • Liu, C. M.
  • Zhou, M.
  • Koh, M. J.
  • Chung, H.
  • Davidson, S. M.
  • Luengo, A.
  • Wang, A. Q.
  • Xu, X.
  • Yasgar, A.
  • Liu, L.
  • Rai, G.
  • Westover, K. D.
  • Vander Heiden, M. G.
  • Shen, M.
  • Gray, N. S.
  • Boxer, M. B.
  • Sabatini, D. M.

publication date

  • 2016

journal

  • Nature Chemical Biology  Journal

subject areas

  • Animals
  • Carbon
  • Cell Proliferation
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors
  • Female
  • Glycolysis
  • Humans
  • Mammary Neoplasms, Experimental
  • Mice
  • Molecular Structure
  • Phosphoglycerate Dehydrogenase
  • Purines
  • Serine
  • Small Molecule Libraries
  • Structure-Activity Relationship
  • Thymidine
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays
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Identity

PubMed Central ID

  • PMC4871733

International Standard Serial Number (ISSN)

  • 1552-4450

Digital Object Identifier (DOI)

  • 10.1038/nchembio.2070

PubMed ID

  • 27110680
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Additional Document Info

start page

  • 452

end page

  • 458

volume

  • 12

issue

  • 6

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