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Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

Academic Article
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Overview

authors

  • Crespo, M.
  • Vilar, E.
  • Tsai, S. Y.
  • Chang, K.
  • Amin, S.
  • Srinivasan, T.
  • Zhang, T.
  • Pipalia, N. H.
  • Chen, H. J.
  • Witherspoon, M.
  • Gordillo, M.
  • Xiang, J. Z.
  • Maxfield, F. R.
  • Lipkin, S.
  • Evans, T.
  • Chen, Shuibing

publication date

  • July 2017

journal

  • Nature Medicine  Journal

subject areas

  • Adenoma
  • Adenomatous Polyposis Coli
  • Adenomatous Polyposis Coli Protein
  • Antibiotics, Antineoplastic
  • Blotting, Western
  • Cell Differentiation
  • Cell Proliferation
  • Colon
  • Colorectal Neoplasms
  • Drug Screening Assays, Antitumor
  • Enteroendocrine Cells
  • Flow Cytometry
  • Fluorescent Antibody Technique
  • Gene Expression Profiling
  • Gentamicins
  • Germ-Line Mutation
  • Goblet Cells
  • Heterocyclic Compounds, 3-Ring
  • Human Embryonic Stem Cells
  • Humans
  • Immunohistochemistry
  • Induced Pluripotent Stem Cells
  • Microscopy, Confocal
  • Mutation
  • Organoids
  • Real-Time Polymerase Chain Reaction
  • Sirolimus
  • Wnt Signaling Pathway
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Identity

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm.4355

PubMed ID

  • 28628110
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Additional Document Info

start page

  • 878

end page

  • 884

volume

  • 23

issue

  • 7

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