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Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics

Academic Article
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Overview

authors

  • Thompson, P.
  • Fleming, R.
  • Bezabeh, B.
  • Huang, F.
  • Mao, S.
  • Chen, C.
  • Harper, J.
  • Zhong, H.
  • Gao, X.
  • Yu, X.
  • Hinrichs, M. J.
  • Reed, M.
  • Kamal, A.
  • Strout, P.
  • Cho, S.
  • Woods, R.
  • Hollingsworth, R. E.
  • Dixit, R.
  • Wu, H.
  • Gao, Changshou
  • Dimasi, N.

publication date

  • August 2016

journal

  • Journal of Controlled Release  Journal

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Cell Line, Tumor
  • Cell Survival
  • Chromatography, High Pressure Liquid
  • Cysteine
  • Drug Design
  • Female
  • Humans
  • Immunoconjugates
  • Mice, Nude
  • Molecular Targeted Therapy
  • Protein Stability
  • Receptors, Fc
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Research

keywords

  • Antibody-drug conjugates
  • Cysteine-engineered antibodies
  • Fc-gamma receptors
  • In vivo efficacy
  • Site-specific conjugation
  • Tubulysin
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Identity

International Standard Serial Number (ISSN)

  • 0168-3659

Digital Object Identifier (DOI)

  • 10.1016/j.jconrel.2016.06.025

PubMed ID

  • 27327768
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Additional Document Info

start page

  • 100

end page

  • 116

volume

  • 236

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