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Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays

Academic Article
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Overview

authors

  • Manfredi, M. G.
  • Ecsedy, J. A.
  • Chakravarty, A.
  • Silverman, L.
  • Zhang, M.
  • Hoar, K. M.
  • Stroud, S. G.
  • Chen, W.
  • Shinde, V.
  • Huck, J. J.
  • Wysong, D. R.
  • Janowick, D. A.
  • Hyer, M. L.
  • Leroy, P. J.
  • Gershman, R. E.
  • Silva, M. D.
  • Germanos, M. S.
  • Bolen, J. B.
  • Claiborne, Christopher Fairman
  • Sells, T. B.

publication date

  • December 2011

journal

  • Clinical Cancer Research  Journal

subject areas

  • Animals
  • Aurora Kinase A
  • Aurora Kinases
  • Azepines
  • Cell Line, Tumor
  • Cell Proliferation
  • Dideoxynucleosides
  • Female
  • Fluorine Radioisotopes
  • HCT116 Cells
  • HeLa Cells
  • Humans
  • Lymphoma
  • Mice
  • Mice, Nude
  • Mice, SCID
  • Mitotic Index
  • Molecular Structure
  • Neoplasms
  • Phosphorylation
  • Positron-Emission Tomography
  • Protein Serine-Threonine Kinases
  • Pyrimidines
  • Spindle Apparatus
  • Tumor Burden
  • Xenograft Model Antitumor Assays
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Identity

International Standard Serial Number (ISSN)

  • 1078-0432

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.ccr-11-1536

PubMed ID

  • 22016509
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Additional Document Info

start page

  • 7614

end page

  • 7624

volume

  • 17

issue

  • 24

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