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Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy

Academic Article
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  • Overview
  • Identity
  • Additional Document Info
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Overview

authors

  • de Dios, A.
  • Shih, C.
  • de Uralde, B. L.
  • Sanchez, C.
  • Del Prado, M.
  • Cabrejas, L. M. M.
  • Pleite, S.
  • Blanco-Urgoiti, J.
  • Lorite, M. J.
  • Nevill, C. R.
  • Bonjouklian, R.
  • York, J.
  • Vieth, Michal
  • Wang, Y.
  • Magnus, N.
  • Campbell, R. M.
  • Anderson, B. D.
  • McCann, D. J.
  • Giera, D. D.
  • Lee, P. A.
  • Schultz, R. M.
  • Li, L. C.
  • Johnson, L. M.
  • Wolos, J. A.

publication date

  • April 2005

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents
  • Arthritis, Experimental
  • Benzimidazoles
  • Binding Sites
  • Biological Availability
  • Collagen
  • Crystallography, X-Ray
  • Drug Design
  • Humans
  • Lipopolysaccharides
  • Macrophages, Peritoneal
  • Mice
  • Mice, Inbred BALB C
  • Mitogen-Activated Protein Kinase 14
  • Models, Molecular
  • Rats
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm048978k

PubMed ID

  • 15801819
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Additional Document Info

start page

  • 2270

end page

  • 2273

volume

  • 48

issue

  • 7

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