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Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic

Academic Article
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Overview

authors

  • Combs, A. P.
  • Zhu, W.
  • Crawley, M. L.
  • Glass, B.
  • Polam, P.
  • Sparks, R. B.
  • Modi, D.
  • Takvorian, A.
  • McLaughlin, E.
  • Yue, Eddy W
  • Wasserman, Z.
  • Bower, M.
  • Wei, M.
  • Rupar, M.
  • Ala, P. J.
  • Reid, B. M.
  • Ellis, D.
  • Gonneville, L.
  • Emm, T.
  • Taylor, N.
  • Yeleswaram, S.
  • Li, Y.
  • Wynn, R.
  • Burn, T. C.
  • Hollis, G.
  • Liu, P. C. C.
  • Metcalf, B.

publication date

  • June 2006

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Benzimidazoles
  • Cell Line
  • Crystallography, X-Ray
  • Humans
  • Models, Molecular
  • Molecular Mimicry
  • Molecular Structure
  • Oligopeptides
  • Phosphorylation
  • Phosphotyrosine
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases
  • Proto-Oncogene Proteins c-akt
  • Receptor, Insulin
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sulfonamides
  • Thiazoles
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm0600904

PubMed ID

  • 16789735
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Additional Document Info

start page

  • 3774

end page

  • 3789

volume

  • 49

issue

  • 13

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