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The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

Academic Article
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Overview

authors

  • Pfefferkorn, Jeff
  • Tu, M.
  • Filipski, K. J.
  • Guzman-Perez, A.
  • Bian, J.
  • Aspnes, G. E.
  • Sammons, M. F.
  • Song, W.
  • Li, J. C.
  • Jones, C. S.
  • Patel, L.
  • Rasmusson, T.
  • Zeng, D.
  • Karki, K.
  • Hamilton, M.
  • Hank, R.
  • Atkinson, K.
  • Litchfield, J.
  • Aiello, R.
  • Baker, L.
  • Barucci, N.
  • Bourassa, P.
  • Bourbounais, F.
  • D'Aquila, T.
  • Derksen, D. R.
  • MacDougall, M.
  • Robertson, A.

publication date

  • December 2012

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Administration, Oral
  • Animals
  • Cell Line, Tumor
  • Diabetes Mellitus, Type 2
  • Drug Design
  • Glucokinase
  • Glucose Tolerance Test
  • Half-Life
  • Humans
  • Hypoglycemic Agents
  • Indazoles
  • Insulin
  • Kinetics
  • Protein Binding
  • Pyrazines
  • Pyrazoles
  • Pyridines
  • Rats
  • Rats, Sprague-Dawley
  • Structure-Activity Relationship
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Research

keywords

  • Glucokinase activator
  • Type 2 diabetes mellitus
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2012.09.082

PubMed ID

  • 23089526
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Additional Document Info

start page

  • 7100

end page

  • 7105

volume

  • 22

issue

  • 23

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