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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Academic Article
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  • Research
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Overview

authors

  • Manfredi, M. G.
  • Ecsedy, J. A.
  • Meetze, K. A.
  • Balani, S. K.
  • Burenkova, O.
  • Chen, W.
  • Galvin, K. M.
  • Hoar, K. M.
  • Huck, J. J.
  • LeRoy, P. J.
  • Ray, E. T.
  • Sells, T. B.
  • Stringer, B.
  • Stroud, S. G.
  • Vos, T. J.
  • Weatherhead, G. S.
  • Wysong, D. R.
  • Zhang, M.
  • Bolen, J. B.
  • Claiborne, Christopher Fairman

publication date

  • March 2007

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

subject areas

  • Administration, Oral
  • Animals
  • Antineoplastic Agents
  • Aurora Kinase A
  • Aurora Kinase B
  • Aurora Kinases
  • Benzazepines
  • Cell Line, Tumor
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors
  • Female
  • Humans
  • Inhibitory Concentration 50
  • Male
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Protein Serine-Threonine Kinases
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Research

keywords

  • apoptosis
  • cancer
  • mitosis
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Identity

PubMed Central ID

  • PMC1820716

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0608798104

PubMed ID

  • 17360485
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Additional Document Info

start page

  • 4106

end page

  • 4111

volume

  • 104

issue

  • 10

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