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Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase

Academic Article
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  • Research
  • Identity
  • Additional Document Info
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Overview

authors

  • Garbaccio, Robert
  • Huang, S.
  • Tasber, E. S.
  • Fraley, M. E.
  • Yan, Y.
  • Munshi, S.
  • Ikuta, M.
  • Kuo, L.
  • Kreatsoulas, C.
  • Stirdivant, S.
  • Drakas, B.
  • Rickert, K.
  • Walsh, E. S.
  • Hamilton, K. A.
  • Buser, C. A.
  • Hardwick, J.
  • Mao, X.
  • Beck, S. C.
  • Abrams, M. T.
  • Tao, W.
  • Lobell, R.
  • Sepp-Lorenzino, L.
  • Hartman, G. D.

publication date

  • November 2007

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Apoptosis
  • Binding Sites
  • Cell Line, Tumor
  • Checkpoint Kinase 1
  • Crystallography, X-Ray
  • Drug Evaluation, Preclinical
  • Enzyme Inhibitors
  • Humans
  • Inhibitory Concentration 50
  • Models, Molecular
  • Molecular Structure
  • Photochemistry
  • Protein Kinases
  • Quinolones
  • Structure-Activity Relationship
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Research

keywords

  • Chek1 kinase
  • Chk1 kinase
  • DNA damaging agents
  • PSA
  • apoptosis
  • benzoisoquinolinones
  • cancer
  • checkpoint escape
  • kinases
  • mitotic arrest
  • p53-deficient cancer
  • photochemistry
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmc1.2007.09.007

PubMed ID

  • 17900896
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Additional Document Info

start page

  • 6280

end page

  • 6285

volume

  • 17

issue

  • 22

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