Ligand-enabled meta-C-H alkylation and arylation using a modified norbornene

Academic Article
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publication date

  • 2015

abstract

  • 2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.