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Identification of pyrrolo[2,1-f][1,2,4] triazine-based inhibitors of Met kinase

Academic Article
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Overview

authors

  • Schroeder, G. M.
  • Chen, X. T.
  • Williams, D. K.
  • Nirschl, David
  • Cai, Z. W.
  • Wei, D.
  • Tokarski, J. S.
  • An, Y. M.
  • Sack, J.
  • Chen, Z.
  • Huynh, T.
  • Vaccaro, W. N.
  • Poss, M.
  • Wautlet, B.
  • Gullo-Brown, J.
  • Kellar, K.
  • Manne, V.
  • Hunt, J. T.
  • Wong, T. W.
  • Lombardo, L. J.
  • Fargnoli, J.
  • Borzilleri, R. M.

publication date

  • March 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Caco-2 Cells
  • Cell Proliferation
  • Cells, Cultured
  • Crystallography, X-Ray
  • Enzyme Inhibitors
  • Ether-A-Go-Go Potassium Channels
  • Glutathione Transferase
  • Hepatocytes
  • Humans
  • Mice
  • Microsomes, Liver
  • Molecular Structure
  • Protein Conformation
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-met
  • Pyrroles
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Growth Factor
  • Stomach Neoplasms
  • Structure-Activity Relationship
  • Triazines
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Research

keywords

  • HGFR
  • Met kinase
  • gastric carcinoma
  • hepatocyte growth factor receptor
  • pyrrolotriazine
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.01.121

PubMed ID

  • 18289854
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Additional Document Info

start page

  • 1945

end page

  • 1951

volume

  • 18

issue

  • 6

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