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BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

Academic Article
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Overview

authors

  • Breuer, C.
  • Stacey, N. J.
  • West, C. E.
  • Zhao, Y.
  • Chory, Joanne
  • Tsukaya, H.
  • Azumi, Y.
  • Maxwell, A.
  • Roberts, K.
  • Sugimoto-Shirasua, K.

publication date

  • November 2007

journal

  • Plant Cell  Journal

abstract

  • How plant organs grow to reach their final size is an important but largely unanswered question. Here, we describe an Arabidopsis thaliana mutant, brassinosteroid-insensitive4 (bin4), in which the growth of various organs is dramatically reduced. Small organ size in bin4 is primarily caused by reduced cell expansion associated with defects in increasing ploidy by endoreduplication. Raising nuclear DNA content in bin4 by colchicine-induced polyploidization partially rescues the cell and organ size phenotype, indicating that BIN4 is directly and specifically required for endoreduplication rather than for subsequent cell expansion. BIN4 encodes a plant-specific, DNA binding protein that acts as a component of the plant DNA topoisomerase VI complex. Loss of BIN4 triggers an ATM- and ATR-dependent DNA damage response in postmitotic cells, and this response coincides with the upregulation of the cyclin B1;1 gene in the same cell types, suggesting a functional link between DNA damage response and endocycle control.

subject areas

  • Amino Acid Sequence
  • Arabidopsis
  • Arabidopsis Proteins
  • Ataxia Telangiectasia Mutated Proteins
  • Brassinosteroids
  • Cell Cycle Proteins
  • Cell Nucleus
  • Cell Proliferation
  • Cell Size
  • Cholestanols
  • Colchicine
  • DNA
  • DNA Damage
  • DNA Topoisomerases, Type I
  • DNA-Binding Proteins
  • G2 Phase
  • Gene Expression Regulation, Plant
  • Genes, Plant
  • Mitosis
  • Molecular Sequence Data
  • Mutation
  • Organ Size
  • Phenotype
  • Plant Epidermis
  • Ploidies
  • Protein Serine-Threonine Kinases
  • Steroids, Heterocyclic
  • Tumor Suppressor Proteins
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Identity

PubMed Central ID

  • PMC2174874

International Standard Serial Number (ISSN)

  • 1040-4651

Digital Object Identifier (DOI)

  • 10.1105/tpc.107.054833

PubMed ID

  • 18055605
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Additional Document Info

start page

  • 3655

end page

  • 3668

volume

  • 19

issue

  • 11

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