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C-H oxidation of ingenanes enables potent and selective protein kinase C isoform activation

Academic Article
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Overview

authors

  • Jin, Y.
  • Yeh, C. H.
  • Kuttruff, C. A.
  • Jorgensen, L.
  • Dünstl, G.
  • Felding, J.
  • Natarajan, S. R.
  • Baran, Phil

publication date

  • November 2015

journal

  • Angewandte Chemie-International Edition  Journal

subject areas

  • Diterpenes
  • Enzyme Activation
  • Isoenzymes
  • Molecular Conformation
  • Oxidation-Reduction
  • Protein Kinase C
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Research

keywords

  • C-H oxidation
  • ingenol
  • natural products
  • protein kinase C
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Identity

PubMed Central ID

  • PMC4832842

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.201507977

PubMed ID

  • 26418078
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Additional Document Info

start page

  • 14044

end page

  • 14048

volume

  • 54

issue

  • 47

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