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Opportunities for treating chronic hepatitis B and C virus infection using RNA interference

Academic Article
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Overview

authors

  • Arbuthnot, P.
  • Longshaw, V.
  • Naidoo, T.
  • Weinberg, Marc

publication date

  • 2007

journal

  • Journal of Viral Hepatitis  Journal

abstract

  • Activating the RNA interference (RNAi) pathway to achieve silencing of specific genes is one of the most exciting new developments of molecular biology. A particularly interesting use of this technology is inhibition of defined viral gene expression. In this review, we discuss the potential application of RNAi to treatment of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Globally, these hepatotropic viruses are the most important causes of cirrhosis and liver cancer. Available treatments have their limitations, which makes development of novel effective RNAi-based therapies for HBV and HCV especially significant. Several investigations carried out in vitro and in vivo are summarized, which demonstrate proof of principle that HBV and HCV can be inhibited by RNAi activators. Challenges facing further development of this technology to a stage of clinical application are discussed.

subject areas

  • Animals
  • Hepacivirus
  • Hepatitis B virus
  • Hepatitis B, Chronic
  • Hepatitis C, Chronic
  • Humans
  • Mice
  • RNA Interference
  • RNA, Messenger
  • RNA, Small Interfering
  • RNA, Viral
  • Viral Proteins
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Research

keywords

  • RNA interference
  • expressed hairpin RNA
  • hepatitis B virus
  • hepatitis C virus
  • short interfering RNA
  • therapy
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Identity

International Standard Serial Number (ISSN)

  • 1352-0504

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2893.2006.00818.x

PubMed ID

  • 17576386
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Additional Document Info

start page

  • 447

end page

  • 459

volume

  • 14

issue

  • 7

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