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Isolation of Drosophila genes encoding G protein-coupled receptor kinases

Academic Article
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Overview

authors

  • Cassill, J. A.
  • Whitney, M.
  • Joazeiro, Claudio Antonio
  • Becker, A.
  • Zuker, C. S.

publication date

  • December 1991

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein kinases that appear to code for G protein-coupled receptor kinases. These proteins share a high degree of sequence homology with the bovine beta-adrenergic receptor kinase. The presence of a conserved family of G protein-coupled receptor kinases in vertebrates and invertebrates points to the central role of these kinases in signal transduction cascades.

subject areas

  • Amino Acid Sequence
  • Animals
  • Blotting, Western
  • Cyclic AMP-Dependent Protein Kinases
  • DNA
  • DNA Probes
  • Drosophila
  • Drosophila Proteins
  • Eye Proteins
  • G-Protein-Coupled Receptor Kinase 1
  • G-Protein-Coupled Receptor Kinase 2
  • GTP-Binding Proteins
  • Molecular Sequence Data
  • Multigene Family
  • Polymerase Chain Reaction
  • Protein Kinases
  • Receptors, Cell Surface
  • Sequence Homology, Nucleic Acid
  • beta-Adrenergic Receptor Kinases
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Research

keywords

  • GUANINE NUCLEOTIDE-BINDING PROTEINS
  • PHOSPHORYLATION
  • RECEPTOR DESENSITIZATION
  • REGULATION
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Identity

PubMed Central ID

  • PMC53074

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.88.24.11067

PubMed ID

  • 1662381
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Additional Document Info

start page

  • 11067

end page

  • 11070

volume

  • 88

issue

  • 24

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