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Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties

Academic Article
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Overview

authors

  • Bezabeh, B.
  • Fleming, R.
  • Fazenbaker, C.
  • Zhong, H.
  • Coffman, K.
  • Yu, X.
  • Leow, C. C.
  • Gibson, N.
  • Wilson, S.
  • Stover, C. K.
  • Wu, H.
  • Gao, Changshou
  • Dimasi, N.

publication date

  • 2017

journal

  • MAbs  Journal

subject areas

  • Angiopoietin-2
  • Animals
  • Antibodies, Bispecific
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Colorectal Neoplasms
  • Humans
  • Immunoglobulin G
  • Mice
  • Protein Engineering
  • Single-Chain Antibodies
  • Vascular Endothelial Growth Factor A
  • Xenograft Model Antitumor Assays
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Research

keywords

  • Antibody engineering
  • bispecific antibody
  • concurrent binding to antigens
  • multispecific antibody
  • single-chain antibody Fv
  • tetravalent antibody
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Identity

PubMed Central ID

  • PMC5297521

International Standard Serial Number (ISSN)

  • 1942-0862

Digital Object Identifier (DOI)

  • 10.1080/19420862.2016.1270492

PubMed ID

  • 27981887
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Additional Document Info

start page

  • 240

end page

  • 256

volume

  • 9

issue

  • 2

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