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Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase

Academic Article
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Overview

authors

  • Davis, B. C.
  • Thorpe, Ian

publication date

  • 2013

journal

  • Proteins-Structure Function and Bioinformatics  Journal

subject areas

  • Allosteric Regulation
  • Hepacivirus
  • Molecular Dynamics Simulation
  • Principal Component Analysis
  • Protein Binding
  • Protein Conformation
  • RNA Replicase
  • Viral Nonstructural Proteins
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Research

keywords

  • NS5B polymerase
  • allostery
  • conformational change
  • molecular simulation
  • non-nucleoside inhibitor
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Identity

PubMed Central ID

  • PMC3943204

International Standard Serial Number (ISSN)

  • 0887-3585

Digital Object Identifier (DOI)

  • 10.1002/prot.24154

PubMed ID

  • 22855387
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Additional Document Info

start page

  • 40

end page

  • 52

volume

  • 81

issue

  • 1

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